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Synthetic, laboratory-made versions of the naturally occurring hormone testosterone, which is produced and secreted by the gonads and adrenal glands in men, and the adrenal glands in women. Hormones requires a battery of oxidative enzymes located in both mitochondria and endoplasmic reticulum. The plasma distribution of cortisol in patients with CBG variants with reduced affinity for cortisol, for example, CBG D367N (Emptoz-Bonneton.
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